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Monday, 7 May 2012

Nate Diaz will get next title shot after UFC on Fox 3 win

Nate Diaz's next opponent is set. After his dominating win over Jim Miller on Saturday night, MMA Junkie reports that Diaz will get the next shot at the UFC lightweight belt.

Though previous reports had Diaz possibly facing off with Anthony Pettis for a title eliminator, UFC president Dana White confirmed that Diaz will get the next title shot after champion Benson Henderson and former champ Frankie Edgar rematch this summer.

In his last three fights, Diaz has a second-round submission over Miller, a decision over Donald Cerrone and a first-round submission win over Takanori Gomi. With an overall record of 16-7, five of his losses have come in the UFC but he has never been stopped in the Octagon. Diaz was last submitted by Hermes Franca at a WEC bout in October of 2006.

Does Diaz deserve the next title shot in the packed UFC lightweight division? Tell us in the comments, on Facebook or on Twitter.

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Sunday, 6 May 2012

ReStore recycles home improvement goods in Siouxland - Sioux ...

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Saturday, 5 May 2012

New technique could identify drugs that help fight broad range of viruses

ScienceDaily (May 4, 2012) ? Results of a new study demonstrate the feasibility of a novel strategy in drug discovery: screening large numbers of existing drugs -- often already approved for other uses -- to see which ones activate genes that boost natural immunity.

Using an automated, high-volume screening technique, researchers at Washington University School of Medicine in St. Louis have identified a cancer drug that enhances an important natural response to viral infection in human cells.

"Over many years of research, we have developed a good understanding of the human body's own mechanisms to fight viruses," says the study's first author Dhara Patel, PhD, a postdoctoral research scholar at Washington University. "Instead of targeting the virus itself, which most current antiviral drugs do, we have designed a strategy to look for chemical compounds that will enhance this innate antiviral system."

The results of the study, led by Michael J. Holtzman, MD, the Selma and Herman Seldin Professor of Medicine, appear May 4 in PLoS ONE.

Of the 2,240 compounds the researchers tested, 64 showed increased activity in the cells' interferon signaling pathway, an important player in the body's response to viruses. The 64 compounds included many different classes of drugs treating conditions as diverse as depression, high blood pressure and ulcers. But the one that stood out is idarubicin, a cancer drug commonly prescribed to treat leukemia, lymphoma and breast cancer. Even at low doses, idarubicin significantly ramps up the interferon signaling system.

In treating cancer, idarubicin stops cells from dividing by blocking a protein that unwinds DNA. As long as DNA remains tightly packed, it can't be copied. And if DNA can't be copied, a cell can't divide. Interestingly, though, the researchers showed that idarubicin's antiviral effects are totally unrelated to what makes it a good cancer drug.

"We tested other cancer drugs that work the same way as idarubicin but have very different structures," Patel says. "Although they act the same way that idarubicin does in cancer cells, they had no effect on the interferon system."

Like many cancer drugs, idarubicin has toxic side effects, so it is unlikely to ever be prescribed for patients fighting viral infections. But, its identification demonstrates that the new strategy works.

"While idarubicin is not something you would give to a patient who has the flu, we are continuing to screen more drugs," Patel says. "We're starting to find compounds from different drug classes that are not so toxic and that have similar properties in enhancing interferon signaling. We're still validating them, but we're very excited about what we're finding."

Traditionally, techniques for drug discovery involve trying to enhance or inhibit a very specific interaction. To treat a particular disease, scientists might try to disable a harmful protein, or replace a missing one, for example. But such approaches assume that altering a specific interaction of interest will result in the desired effect.

"I think our technique accepts the fact that we don't understand everything that's going on in the cell," Patel says. "Instead of looking at one particular interaction, we measure the downstream effects."

She compares it to driving a car and trying to make it go faster.

"Traditionally, we would pick a specific part -- a part of the car that we think is responsible for speed -- and then test compounds that alter the part in a way that we think will make the car go faster," she says. "With our approach, we don't assume we know what is responsible for speed. Instead, we take entire cars, treat them with many different compounds, and just see which ones go faster."

Patel says this screening technique is unusual because it can identify drugs that enhance the body's own immune response to a broad range of viruses, unlike a vaccine, which only protects against a specific virus.

The method has also shed light on how some compounds with known antiviral properties actually fight viruses. In addition to cancer drugs, antidepressants and blood pressure medications, the initial 64 drugs they identified with increased interferon activity included some known antiviral drugs.

"We already knew some of these compounds had antiviral properties, we just didn't know why," Patel says. "Now we're starting to find out how they actually work."

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The above story is reprinted from materials provided by Washington University in St. Louis, via Newswise.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

Journal Reference:

Patel DA, Patel AC, Nolan WC, Zhang Y, Holtzman, MJ. High throughput screening for small molecule enhancers of the interferon signaling pathway to drive next generation antiviral drug discovery. PLoS ONE, May 4, 2012 DOI: 10.1371/journal.pone.0036594?

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

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Nokia Weighs In On Investors? Class-Action Lawsuit: It Has ?No Merit?

Nokia may be busy suing the likes of RIM, HTC, and Viewsonic over the infringement of a long list of wireless patents, but the Finnish company should watch their backs -- now they're the target of a class-action lawsuit from a shareholder because their plan to embrace to Windows Phone hasn't yielded the right results. But are they concerned about it? Not if their official statement on the situation is any indication -- Nokia has just reached out to say that they are "reviewing the allegations contained in the complaint and believes that they are without merit. Nokia will defend itself against the complaint."

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What killed Lenin? Stress didn't help, poison eyed

In this undated photo, Soviet leader Vladimir Lenin is seen on his death bed. Syphilis probably didn't kill Lenin. Stress, on the other hand, didn't help, and poison may have done him in. That's the conclusion of a doctor and a historian who examined medical records and other evidence for an annual University of Maryland School of Medicine conference on the deaths of famous figures. UCLA neurologist Dr. Harry Vinters and Russian historian Lev Lurie reviewed Lenin's records for an annual University of Maryland School of Medicine conference that opens Friday, May 4, 2012 in Baltimore on famous people's deaths. (AP Photo)

In this 1921 photo, Soviet leader Vladimir Lenin speaks at a celebration in Russia. Syphilis probably didn't kill Lenin. Stress, on the other hand, didn't help, and poison may have done him in. That's the conclusion of a doctor and a historian who examined medical records and other evidence for an annual University of Maryland School of Medicine conference on the deaths of famous figures. UCLA neurologist Dr. Harry Vinters and Russian historian Lev Lurie reviewed Lenin's records for an annual University of Maryland School of Medicine conference that opens Friday, May 4, 2012 in Baltimore on famous people's deaths. (AP Photo)

Soviet leader Vladimir Lenin is seen in an undated photo. Syphilis probably didn't kill Lenin. Stress, on the other hand, didn't help, and poison may have done him in. That's the conclusion of a doctor and a historian who examined medical records and other evidence for an annual University of Maryland School of Medicine conference on the deaths of famous figures. UCLA neurologist Dr. Harry Vinters and Russian historian Lev Lurie reviewed Lenin's records for an annual University of Maryland School of Medicine conference that opens Friday, May 4, 2012 in Baltimore on famous people's deaths. (AP Photo)

In this 1922 photo, Vladimir Lenin, left, sits in a park with Joseph V. Stalin. Syphilis probably didn't kill Lenin. Stress, on the other hand, didn't help, and poison may have done him in. That's the conclusion of a doctor and a historian who examined medical records and other evidence for an annual University of Maryland School of Medicine conference on the deaths of famous figures. UCLA neurologist Dr. Harry Vinters and Russian historian Lev Lurie reviewed Lenin's records for an annual University of Maryland School of Medicine conference that opens Friday, May 4, 2012 in Baltimore on famous people's deaths. (AP Photo)

BALTIMORE (AP) ? Stress, family medical history or possibly even poison led to the death of Vladimir Lenin, contradicting a popular theory that a sexually transmitted disease debilitated the former Soviet Union leader, a UCLA neurologist said Friday.

Dr. Harry Vinters and Russian historian Lev Lurie reviewed Lenin's records Friday for an annual University of Maryland School of Medicine conference that examines the death of famous figures.

The conference is held yearly at the school, where researchers in the past have re-examined the diagnoses of figures including King Tut, Christopher Columbus, Simon Bolivar and Abraham Lincoln.

The 53-year-old Soviet leader suffered several strokes before dying in 1924 and what caused them isn't clear.

An autopsy found blood vessels in his brain were extremely hardened, results that have been difficult to understand, said Dr. Philip Mackowiak, who organizes the yearly event.

"Number one, he's so young and number two, he has none of the important risk factors," Mackowiak said.

Lenin didn't smoke ? he never let smokers near him. He also didn't have diabetes, wasn't overweight and the autopsy didn't find any evidence of high blood pressure, said Mackowiak, director of the medical care clinical center of the VA Maryland Health Care System, a co-sponsor of the event.

There was "considerable suspicion" among Russians at the time of Lenin's death that syphilis was to blame, Mackowiak said.

However, family history appears to have worked more against Lenin, Vinters said.

Lenin was treated for syphilis using the primitive medications available at the time, and while the sexually transmitted disease can cause strokes, there is no evidence from his symptoms or the autopsy that was the case with Lenin, Vinters said.

The Soviet leader's father died at 54 and both may have been predisposed to hardening of the arteries. Stress also is a risk factor for strokes, and there's no question the communist revolutionary was under plenty of that, the neurologist said.

"People were always trying to assassinate him, for example." Vinters said.

Lurie, a St. Petersburg-based expert in Russian history and politics who also spoke at the conference, said that while Lenin had several strokes, he believes Josef Stalin may finished him off with poison, a theory that Vinters said is a possibility.

Lenin's health had been growing worse over time. In 1921, he forgot the words of a major speech and he had to learn to speak again and write with his left hand after one stroke. A major stroke later left him paralyzed on one side and unable to speak.

However, Lurie said Lenin had recovered enough in early 1924 that he celebrated the new year and went hunting. Lenin, who supported Stalin's rise to power, may have realized he made a mistake and began aligning himself with Leon Trotsky, which caused Stalin to poison Lenin, the historian said.

Poisoning, in fact, eventually became one of Stalin's favorite methods of disposing of enemies, Lurie said.

"The funny thing is that the brain of Lenin still is preserved in Moscow, so we can investigate," Lurie said.

Lenin's embalmed body also still lies on public display in a Red Square mausoleum almost 20 years after the collapse of the communist state he helped bring to life.

Vinters, who reviewed autopsy records and the leader's clinical history, said toxicology tests that might have revealed poisoning were not conducted during the autopsy. Reports from the time also show Lenin was active and talking a few hours before his death.

"And then he experienced a series of really, really bad convulsions which is quite unusual for someone who has a stroke," Vinters said.

Associated Press

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New 'Amazing Spider-Man' Trailer: Five Key Scenes

We take a closer look at the latest action-packed sneak peek.
By Kara Warner

Andrew Garfield in "The Amazing Spider-Man"
Photo: Columbia Pictures

Holy web-slingers, Spidey fans: Another trailer for "The Amazing Spider-Man" has arrived!

While there are several familiar scenes from the first two epic teasers weaved into this exciting new two-and-a-half minutes, director Marc Webb has introduced a bunch of intriguing new elements into the new footage.

Here are five key scenes from the latest trailer:

Lonely Boy
Webb told us previously that the fact that Peter Parker is an orphan will play heavily into the story of this film, which is very much exemplified by the multiple "lonely boy" shots of Parker standing atop various buildings or walking by himself through the city streets with a forlorn look on his face. Not to mention Andrew Garfield's voice-over: "This life is not an easy one. I've made enemies, powerful enemies. I've put people I love in danger, but the one thing that has haunted me my entire life is finding the truth about my parents ... "

"I think there's a real emotional consequence to someone who's left by their parents when they're 7 or 8 years old," Webb has said. "And that contributes to sort of this trickster, chip-on-his-shoulder attitude."

Other Mischief May Come
Speaking of Parker's trickster side, we get another glimpse of his comedic and sarcastic sensibilities during his encounter with a carjacker, as shown in the previous trailer. What's new and fun this time around is Parker taunting the guy: "You found my weakness!" Parker says to the carjacker sarcastically. "It's small knives!"

The other intriguing and very possibly mischievous element in play here is the quick shot we see of Parker looking up at the impossibly tall and menacing Oscorp skyscraper. Yes, we know Parker is interested in the building because of its ties to his father and that Oscorp ID card he holds onto, but we can't help but feel a little bit of foreshadowing is at play in knowing what plays out with one Norman Osborn.

Lizard in a Lab Coat
Behold, the recently transformed, very dangerous-looking Lizard crumpled on the floor and bursting out of his lab coat — or the lab coat of his former self, Dr. Curt Connors (played by Rhys Ifans). We've seen some very quick shots of the film's central villain before, but this trailer offers us multiple glimpses at the before-and-after of Dr. Connors. And he is not at all a nice guy in his hulking green lizardy form ("Avengers" pun un-intended). We see the Lizard hurling innocent people around and later in heated pursuit of our heroic web-slinger.

Mystery Man With Intel
Speaking of the pre-reptilian Dr. Connors, there is a very brief, but intriguing interrogation-like scene in the trailer between Connors and an unidentified older gentleman. The gentleman looks to have long-ish white hair and is shown in a sort of shadowy silhouette asking the good doctor a very pointed question about Peter Parker and his parents. "Did you tell the boy about his father?" he says to Connors. We don't get to hear the Doc's response during this brief exchange, but the worried-but-stubborn look on Connors' face says the man is definitely withholding some key information that will undoubtedly prove to be of major importance to Parker down the line.

Action, Action and More Action
And just like all great superheroic trailers before it, Webb spends the last minute or so of his new trailer impressing us with tons of action. We see Parker-as-Spider-Man's extraordinary athleticism in some scenes of good old-fashioned chasery: He dodges police officers, carjackers and the Lizard, not to mention one impressive feat wherein he appears to be holding a burning car from plunging into a river — which, by the way, totally reminds us of a scene from Sam Raimi's "Spider-Man," whether that was intended or not; we'll have to see the finished film to decide. There is also more demonstration of Spidey's fancy web-slingers as he masters his skills with swinging from building to building and stealthily sliding into rooms upside down.

Check out everything we've got on "The Amazing Spider-Man."

For breaking news and previews of the latest comic book movies — updated around the clock — visit SplashPage.MTV.com.